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Posted on January 25, 2018March 6, 2026

Welcome to the Smith Lab

Welcome to the laboratory of Dr. Nathan Anthony Smith  in the Department of Neuroscience and Del Monte Institute for Neuroscience at the University of Rochester School of Medicine and Dentistry.

In Vivo Ca2+ Imaging in an awake GFAP-CreER/GCaMP5G mouse.


In Vivo Ca2+ Imaging in an awake Aldh1l1-CreER/GCaMP5G mouse

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Launch of “Mentoring with INTENT”- GEPA SMD Mentorship Training Program (Begins March 18).

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    New Lab PrePrint Out: Our latest study reveals that aging disrupts the mitochondrial MICOS complex, causing cristae fragmentation and connectivity loss, which impairs neuronal energy and excitability, particularly in brain regions vulnerable to Alzheimer's. This collaborative…

    — Dr. Nathan A. Smith (@NathanASmith1) December 16, 2025

    Location

    University of Rochester
    School of Medicine and Dentistry

    601 Elmwood Avenue
    Box 603
    Rochester, NY 14642
    Nathan_Smith@urmc.rochester.edu

    News

    1. December 4, 2017: Dr. Nathan A. Smith was appointed to Principal Investigator and Assistant Professor of Pediatrics, Pharmacology, and Physiology and at Children’s National Health System and George Washington University School of Medicine and Health Sciences.
    2. January 30, 2018: The Dark Side of tracking Ca2+ in cells: http://stke.sciencemag.org/content/11/515/eaal2039
    3. Winner of the 2018 Children’s National President’s Award for Innovative Research: https://innovationdistrict.childrensnational.org/presidents-award-highlights-innovative-work-by-early-career-researchers/
    4. Promising Talent Finds a Career Path at Children’s National: https://threespot.github.io/cri-annual-report/articles/highlights-smith.html
    5. Dr. Nathan A. Smith (Principal Investigator) received notice that his NIH NINDS Faculty K01 award will be funded Feb. 2019.
    6. Congrats to @SmithLab2018 summer interns Seowon and Julia for receiving a Childrens Research Institute Summer Intern Stipend Awards at Children’s National Medical Center. 
    7. Dr. Nathan A. Smith (Co-Principal Investigator) received notice that our collaborative NSF Frontiers Grant between Children’s National, Stony Brook Medicine, and MGH will be awarded and starts October 1, 2019.
    8. University of Rochester School of Medicine Del Monte Institute For Neuroscience Alumni Awardee -presented at SFN 2019 in Chicago.
    9. Dr. Nathan A. Smith (Principal Investigator) received notice that his DOD Army Research grant will be awarded and starts July 1, 2020.
    10. Recipient of the Edward M. Connor Family Endowment for Innovation in Research January 1, 2021
    11. “Education is key.” Neuroscientist Nathan A. Smith, M.S. (’10), Ph.D. (’13), returns in leadership role
    12. Dr. Nathan A. Smith elected as a 2021 AAAS Fellow
    13. April 1, 2022: Dr. Nathan A. Smith was appointed Principal Investigator and Associate Professor of Neuroscience and Associate Dean of Equity and Inclusion at University of Rochester School of Medicine and Dentistry.
    14. Dr. Nathan A. Smith receives 2023 Graduate Student Society Advocacy Award.
    15. Dr. Nathan A. Smith receives notice that his DOD grant was renewed February 2024.
    16. Dr. Nathan A. Smith appointed Inaugural Associate Dean for Research Mentorship at the University of Rochester School of Medicine and Dentistry.
    17. Dr. Nathan A. Smith named a 2025 AMSNDC Leadership Fellow
    18. Congratulations to Sid on successfully passing his qualifying exam and advancing to Ph.D. candidacy
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